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Now L - Citrulline 750mg 90 Veg - Caps - Nature's Source Inc

Now L-Citrulline 750mg 90 Veg-Caps

$31.69

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What is Citrulline?

L-Citrulline, a naturally occurring non-essential amino acid, is essential for detoxification of the liver from ammonia which is a waste product from oxidation, generated during rebuilding and muscle recovery.

L-Citrulline is a precursor of L- Arginine and so it plays a role in regulating Nitric Oxide (NO) production.

Citrulline, which is found in high concentrations in the liver, is not a component of any major proteins or enzymes. The amino acid citrulline is required to detoxify the liver from ammonia, which is a waste product of the body from oxidation.

Citrulline promotes energy and stimulates the immune system.

This unique amino acid is created in the urea cycle by the addition of carbon dioxide and ammonia to L-Ornithine. It is then combined with aspartic acid to form arginosuccinic acid, which is subsequently metabolized into the amino acid called L-Arginine.

Citrulline is an amino acid that is part of the L-arginine NO (nitric oxide) pathway and helps prevent shortages of arginine because it can be converted to arginine.

When arginine is converted to nitric oxide (NO), it improves arterial blood flow and relaxes blood vessels. NO also has antioxidant functions which protects cardiovascular tissues from oxidative damage leading to atherosclerosis (hardening of the arteries).


Arginine is known to be involved with wound healing, removing excess ammonia from the body, protein and sperm cell synthesis and promoting the secretion of essential hormones (growth hormone, glucagon for energy, insulin for blood sugar control, etc.).

Dietary citrulline is clinically better than ornithine at supporting arginine levels and functions, even though citrulline is converted to ornithine as an intermediate step to its conversion to arginine. Arginine can also be converted back to citrulline.

Supporting Science:

Citrulline/malate promotes aerobic energy production in human exercising muscle. British Journal of Sports Medicine. 2002.

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology. 2008.

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